WARNING: the foods we cook for Abby are safe for her, but not necessarily for everyone. Please confirm any ingredients are safe for you before using in your diet. Food Allergies can kill and the best policy is complete avoidance. Read this post for more info.

Saturday, March 24, 2012

PQQ? As important as CoQ10??

So my favorite little bird sent me a new supplement to google with coffee- PQQ

So, I started at my beloved Wikipedia!

Of interest: Supplementation benefits

PQQ is taken as a dietary supplement to support mitochondrial health and cellular energy production, and to protect the body from oxidative stress. Most notably, PQQ stimulates the spontaneous growth of new mitochondria in aging cells, and activates genes that govern mitochondrial reproduction, protection, and repair.
[edit]Antioxidant capacity and role in mitochondrial health
Mitochondria are the primary engines of almost all bioenergy production in the human body and are among the most vulnerable physiological structures to destruction from oxidative damage. Scientists now recognize mitochondrial dysfunction as a key biomarker of aging.[13] [14][15][16][17][18]Relative to cellular DNA, mitochondrial DNA possesses few defenses against free radical damage, and is dependent upon antioxidants for protection. [19][20]PQQ’s powerful free radical–scavenging capacity provides the mitochondria with superior antioxidant protection due to its high molecular stability and the role it plays in energy transfer directly within the mitochondria. Unlike other antioxidants, the exceptional molecular stability of PQQ allows it to carry out thousands of electron transfers without undergoing molecular breakdown [21]
PQQ is especially effective in neutralizing superoxide and hydroxyl radicals,[22][23] two prominent causes of mitochondrial dysfunction.
According to a University of California at Davis study, “PQQ is 30 to 5,000 times more efficient in sustaining redox cycling (mitochondrial energy production) . . . than other common [antioxidant compounds], e.g. Ascorbic Acid (Vitamin C).”[24]

So next up I headed to do a Google "scholar" search. First thing I noted was that there was a lot of research during the 80's and 90's..and then it slowed down and picked up again in 2005- which makes sense since the study of Mitochondria expanded considerably in the past 10 years and anything that might influence mitochondria would be of interest.

Like usual, many of the articles I would have liked to have read were locked and would have cost me 30 bucks :-( But, did find THIS one-

Here is the Abstract:

The effects of pyrroloquinoline quinone (PQQ) and coenzyme Q10 (Co Q10), either alone or together, on the learning ability and memory function of rats were investigated. Rats fed a PQQ-supplemented diet showed better learning ability than rats fed a CoQ10-supplemented diet at the early stage of the Morris water maze test. The combination of both compounds resulted in no significant improvement in the learning ability compared with the supplementation of PQQ alone. At the late stage of the test, rats fed PQQ-, CoQ10- and PQQ + CoQ10-supplemented diets showed similar improved learning abilities. When all the groups were subjected to hyperoxia as oxidative stress for 48 h, rats fed the PQQ- and CoQ10 supplemented diets showed better memory function than the control rats. The concurrent diet markedly improved the memory deficit of the rats caused by oxidative stress. Although the vitamin E-deficient rats fed PQQ or CoQ10 improved their learning function even when subjected to hyperoxia, their memory function was maintained by PQQ rather than by CoQ10 after the stress. These results suggest that PQQ is potentially effective for preventing neurodegeneration caused by oxidative stress, and that its effect is independent of either antioxidant’s interaction with vitamin E.
Keywords: cognitive deficit, oxidative stress, pyrroloquinoline quinone, coenzyme Q10
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So this supplement has my interest and attention.. Since Abby struggles with any supplement by mouth, either GI upset or odd reactions I figured it might help to get a list of food where this PQQ is found in higher levels-

This LINK was the first I found that had a food chart :

Then I found this NIH PDF with another chart pretty much the same, but nice to know that the original chart I found was accurate, and most interesting to me was this research was posted in -1995 which was the year Abby was born..

Broad bean
Green soybeans
Sweet potato
Green pepper
Kiwi fruit
Green tea
Oolong (tea)
Fermented soybeans (natto)
Miso (bean paste)
Tofu (bean curd)

These are foods that I have always and regularly prepared for meals around here. Abby out of all of us has always eaten the fewest of them because of her allergies/sensitivities. (Minus the Whiskey and WINE and Sake!!! LOL)

Very interesting information. What I wonder is, if PQQ was known even the 80's by government and private research as a "key" supplement, why am I just learning about it now?


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