WARNING: the foods we cook for Abby are safe for her, but not necessarily for everyone. Please confirm any ingredients are safe for you before using in your diet. Food Allergies can kill and the best policy is complete avoidance. Read this post for more info.

Monday, April 30, 2012

Multiple Chemical Sensitivity- and Mito too?

Definition: (from the MCS America site)

Multiple Chemical Sensitivity is “a diagnostic label for people who suffer multi-system illnesses as a result of contact with, or proximity to, a variety of airborne agents and other substances." (EPA)

General Information

Multiple Chemical Sensitivities (MCS) was identified in a 1989 multidisciplinary survey of 89 clinicians and researchers, and modified in 1999. Top consensus criteria (Multiple chemical sensitivity: a 1999 consensus, 1999) for MCS define the condition by these criteria:

A chronic condition.
Symptoms recur reproducibly.
Symptoms recur in response to low levels of chemical exposure.
Symptoms occur when exposed to multiple unrelated chemicals.
Symptoms improve or resolve when trigger chemicals are removed.
Multiple organ systems are affected.

Toxic substances that people with MCS become disabled by include any quantity of exposures to pesticides, secondhand smoke, alcohol, fresh paint, scented products and perfumes, candles, fragrances, food preservatives, flavor enhancers, aerosols, tap water, cosmetics, personal care products, new carpets, petroleum products, formaldehyde, outdoor pollutants, newspaper ink, cleaning compounds, printing and office products, and other synthetically derived chemicals. Some also become ill from natural products that are highly concentrated such as natural orange cleaners due to high volatile organic compound and pesticide concentration. Symptoms can range from minor annoyances (headache, runny nose) to life-threatening reactions (seizures, anaphalaxis).


Older article, but found the mutations of interest- full article can be found via this LINK

Case-control study of genotypes in multiple
chemical sensitivity: CYP2D6, NAT1, NAT2,
PON1, PON2 and MTHFR

Gail McKeown-Eyssen,
1,2
Cornelia Baines,
1
David EC Cole,
3,4,5
Nicole Riley,
1
Rachel F Tyndale,
6,7
Lynn Marshall
8,9
and Vartouhi Jazmaji
1
Accepted 10 May 2004
Background Impaired metabolism of toxic chemicals is a postulated mechanism underlying
multiple chemical sensitivity (MCS). Because genetic variation alters the rate of
chemical metabolism, this study was designed to determine if MCS cases differed
from controls for genetic polymorphisms in drug-metabolizing enzymes.
Methods Female Caucasian participants (203 cases and 162 controls) were drawn from a
larger case-control study based on a reproducible and validated case definition.
Common polymorphisms for CYP2D6, NAT1, NAT2, PON1, and PON2 were
genotyped.
Results Comparing cases and controls, significant differences were found in genotype
distributions for CYP2D6 (P = 0.02) and NAT2 (P = 0.03). Compared with the
referent homozygous inactive (CYP2D6) or slow (NAT2) metabolizers, the odds
for being CYP2D6 homozygous active (OR = 3.36, P = 0.01) and NAT2 rapid
(OR = 4.14, P = 0.01) were significantly higher in cases than controls. The odds
for being heterozygous for PON1-55 (OR = 2.05, P = 0.04) and PON1-192 (OR =
1.57, P = 0.04) were also significantly higher in cases.
Conclusions A genetic predisposition for MCS may involve altered biotransformation of
environmental chemicals. The CYP2D6 enzyme activates and inactivates toxins;
the NAT2 enzyme bioactivates arylamines to protein-binding metabolites. A
gene–gene interaction between CYP2D6 and NAT2 suggested that rapid
metabolism for both enzymes may confer substantially elevated risk (OR = 18.7,
P = 0.002). Our finding parallels others’ observation of a link between PON1
heterozygosity and neurological symptoms in Gulf War syndrome. This first
demonstration of genetic variation in drug-metabolizing enzymes in association
with MCS requires replication. However, it suggests new research directions on
genetically variable toxin pathways that might be important in MCS.
Keywords Multiple chemical sensitivity, environmental intolerance, environmental
hypersensitivity, unexplained symptoms, genotype.

3 comments:

Jenna said...

That is so interesting, it sounds a lot like Abby and Lady A. Has Kristi read this yet?

Diane said...

I think I sent it to her, or on one of the boards or she will stop by and see what I am blabbing about now and then :-) But you are right, I think there is a connection between Abby's depletion they found, mast,allergies,and MCS. Now just have to "prove" it :-)

Anonymous said...

....I live in spring, and I think I have MCS. Where did you get help?

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