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Monday, July 23, 2012

Got Nicotinamide Riboside?


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I got this great article in my email yesterday. It caught my attention very quickly because my focus is my weight and Abby is all about Mito.

My one question would be, does pasteurization destroy Nicotinamide Riboside? I know that once milk is pasteurized they end up adding all the vitamins. I suspect, this would be more available in raw milk. Perhaps Nicotinamide Riboside is part of the reason that so many folks with chronic illness's feel better when they start drinking raw milk or kefir? Just guessing but it would add one more benefit to the raw movement which I fully support.


Here is the full article LINK or this LINK

Now I will cut and copy what I thought the highlights were!

Highlights
NR efficiently increases NAD+ levels in mammalian cells and tissues
NR supplementation increases SIRT1 and SIRT3 activities
NR largely prevents the detrimental metabolic effects of high-fat feeding
NR enhances mitochondrial function and endurance performance

"The bottom line is that nicotinamide riboside improves the function of mitochondria, the cell's energy factories."

A novel form of vitamin B3 found in milk in small quantities produces remarkable health benefits in mice when high doses are administered, according to a new study conducted by researchers at Weill Cornell Medical College and the Polytechnic School in Lausanne, Switzerland.

The findings, published June 6 by Cell Metabolism, reveal that high doses of the vitamin precursor, nicotinamide riboside (NR) - a cousin of niacin:

• Prevented obesity in mice that are fed a fatty diet (reduced weight gain 60% vs those not supplemented with NR), while controlling cholesterol levels, and also

• Increased muscle performance/strength,

• Improved energy expenditure and endurance,

• Prevented the development of diabetes seen in the unsupplemented mice, and improved insulin sensitivity when the mice were fed a normal diet,

• All without side effects or toxicity.
"This study is very important. It shows that in animals, the use of NR offers the health benefits of a low-calorie diet and exercise - without doing either one," says Dr. Anthony Sauve, associate professor of Pharmacology at Weill Cornell.

The animal studies were led by Drs. Carles Canto and Johan Auwerx, at Ecole Polytechnique de Lausanne’s energy metabolism lab, and it was Dr. Sauve who invented a simple method for efficiently synthesizing NR in large scale.

• Dr. Sauve was also first to show that NR increases nicotinamide adenine dinucleotide (NAD) levels in mammalian cells. NAD is a central player in energy metabolism.

• He is a leader in investigating how NAD can signal adaptation in cells and in physiology.

• And he believes the research suggests the effects of NR can be even broader.
"The bottom line is that NR improves the function of mitochondria, the cell's energy factories,” Dr. Sauve says.

“Mitochondrial decline is the hallmark of many diseases associated with aging, such as cancer and neurodegeneration, and NR supplementation boosts mitochondrial functioning," he adds.


I did a quick google search to see if there was a supplement available, I did not find one but found a few companies claiming they are working on one. Also it does appear in "other foods" in trace amounts but it is not something they have ever measured before to see which foods had the best levels, so I am hoping they will come up with a food list soon!

A terrific new finding for anyone with any type of Mitochondrial dysfunction- from Fibro- to chronic fatigue to huntingtons to depletions. I will be watching this one closely!

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