Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies
A few cut and copies from the article:
" Glyphosate, the active ingredient in Roundup®, has also been shown to severely deplete Mn levels in plants. Here, we investigate the impact of Mn on physiology, and its association with gut dysbiosis as well as neuropathologies such as autism, Alzheimer's disease (AD), depression, anxiety syndrome, Parkinson's disease (PD), and prion diseases. Glutamate overexpression in the brain in association with autism, AD, and other neurological diseases can be explained by Mn deficiency. Mn superoxide dismutase protects mitochondria from oxidative damage, and mitochondrial dysfunction is a key feature of autism and Alzheimer’s. Chondroitin sulfate synthesis depends on Mn, and its deficiency leads to osteoporosis and osteomalacia. Lactobacillus, depleted in autism, depend critically on Mn for antioxidant protection. Lactobacillus probiotics can treat anxiety, which is a comorbidity of autism and chronic fatigue syndrome. Reduced gut Lactobacillus leads to overgrowth of the pathogen, Salmonella, which is resistant to glyphosate toxicity, and Mn plays a role here as well. Sperm motility depends on Mn, and this may partially explain increased rates of infertility and birth defects. We further reason that, under conditions of adequate Mn in the diet, glyphosate, through its disruption of bile acid homeostasis, ironically promotes toxic accumulation of Mn in the brainstem, leading to conditions such as PD and prion diseases.
"Adjuvants in pesticides are synergistically toxic with the active ingredient. Mesnage et al. showed that Roundup® was 125 times more toxic than glyphosate by itself. These authors wrote: “Despite its relatively benign reputation, Roundup® was among the most toxic herbicides and insecticides tested.”"
"There are multiple pathways by which glyphosate could lead to pathology. A major consideration is that our gut bacteria do have the shikimate pathway, and that we depend upon this pathway in our gut bacteria as well as in plants to supply us with the essential aromatic amino acids, tryptophan, tyrosine, and phenylalanine. Methionine, an essential sulfur-containing amino acid, and glycine, are also negatively impacted by glyphosate. Furthermore, many other biologically active molecules, including serotonin, melatonin, melanin, epinephrine, dopamine, thyroid hormone, folate, coenzyme Q10, vitamin K, and vitamin E, depend on the shikimate pathway metabolites as precursors. Gut bacteria and plants use exclusively the shikimate pathway to produce these amino acids. In part because of shikimate pathway disruption, our gut bacteria are harmed by glyphosate, as evidenced by the fact that it has been patented as an antimicrobial agent."
"Rossignol et al. have reviewed the evidence for environmental toxicant exposure as a causative factor in autism, and they referenced several studies showing that urinary excretion of porphyrin precursors to heme is found in association with autism, suggesting impaired heme synthesis. Impaired biliary excretion leads to increased excretion of heme precursors in the urine, a biomarker of multiple chemical sensitivity syndrome. We later discuss the ability of glyphosate to disrupt bile homeostasis, which we believe is a major source of its toxic effects on humans.
Glyphosate is a likely cause of the recent epidemic in celiac disease. Glyphosate residues are found in wheat due to the increasingly widespread practice of staging and desiccation of wheat right before harvest. Many of the pathologies associated with celiac disease can be explained by disruption of CYP enzymes. Celiac patients have a shortened life span, mainly due to an increased risk to cancer, most especially non-Hodgkin's lymphoma, which has also been linked to glyphosate.[85,253] Celiac disease trends over time match well with the increase in glyphosate usage on wheat crops.
Glyphosate is also neurotoxic. Its mammalian metabolism yields two products: Aminomethylphosphonic acid (AMPA) and glyoxylate, with AMPA being at least as toxic as glyphosate. Glyoxylate is a highly reactive glycating agent, which will disrupt the function of multiple proteins in cells that are exposed. Glycation has been directly implicated in Parkinson's disease (PD). Glyphosate has been detected in the brains of malformed piglets. In a report produced by the Environmental Protection Agency (EPA), over 36% of 271 incidences involving acute glyphosate poisoning involved neurological symptoms, indicative of glyphosate toxicity in the brain and nervous system.[122"
If that isn't enough to make you give up the boxed and non organic food I don't know what would be.. Elemental formulas are not organic. 50 percent or more of elemental formula's is made from corn which will have been exposed to some of the highest amounts of Round Up. Sadly, even some organics are now testing positive for Round up because our water table is contaminated and it takes a lot of time for Round Up to breakdown.
Want to test your urine or water for Round up? See exactly how saturated your body is?
Moms Across America is offering the testing for a reasonable price.